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Mirati’s KRAS Inhibitor Gains Edge On Efficacy, But Safety Trails Amgen’s Competing Drug

 
• By Alaric DeArment

Mirati’s adagrasib seems to have better efficacy data while Amgen’s sotorasib has the safety advantage, but oncologists aren’t issuing a verdict yet. 

Digital illustration of lung cancer cells in color background

Long-awaited data on Mirati Therapeutics, Inc.’s KRAS G12C inhibitor in non-small cell lung cancer (NSCLC), as well as colorectal cancer (CRC), sparked excitement from observers, but raise questions about how the drug’s safety-efficacy profile stacks up against a similar drug from Amgen, Inc. The efficacy data on KRAS G12C inhibitors have also sparked discussion about combination strategies, particularly with SHP-2 inhibitors, another emerging class of small molecules.

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• By Lisa Takagi

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• By Andrew McConaghie, Edwin Elmhirst, and Dexter Jie Yan

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