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Assembly Falls Well Short In Attempt At Finite HBV Therapy

 
• By Joseph Haas

Biotech tried to show that a core inhibitor combined with standard hepatitis B therapy could yield lasting benefit after treatment. Vebicorvir will continue to be studied as a chronic treatment in HBV.

liver
Assembly stills see plenty of paths forward in hep B despite Phase II finite therapy miss

Antivirals are typically used as chronic treatment to suppress the hepatitis B virus, but several companies are attempting to achieve virtual cures of the virus. Assembly Biosciences, Inc., focused on core inhibitors of HBV, tried to achieve a bridge between chronic treatment and a cure with finite therapy – a limited course of treatment that would yield lasting viral suppression – but a Phase II combination study fell well short of its mark, as 39 of 41 patients relapsed after treatment was stopped.

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