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CymaBay Focused On PBC With Seladelpar, Wants Partner For NASH

 
• By Joseph Haas

With an FDA clinical hold lifted, CymaBay plans to initiate a new Phase III in primary biliary cholangitis early in 2021. It also hopes to partner the drug in NASH with a company developing a metabolic drug for the disease.

scientists doing lab research on digital screen
CymaBay's PBC candidate shows fibrosis, inflammation, liver marker benefits

Positive findings from CymaBay Therapeutics, Inc.’s halted Phase III trial of seladelpar in primary biliary cholangitis, presented at the American Association for Study of Liver Disease, are helping get the PPAR delta agonist back on track. CEO Sujal Shah told Scrip that while PBC remains the top priority for his company, it also hopes to position seladelpar as part of combination therapy in non-alcoholic steatohepatitis with a drug that can provide metabolic benefit to patients.

The past 12 months have brought turmoil to CymaBay, which announced on 25 November 2019 that it was suspending the Phase III ENHANCE study of seladelpar as well as a...

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