Stock Watch: Like Moths To The Unvalidated Flame

Considering Target Validation In Light Of Novartis’s Lung Cancer Failure

Leaving the validation of a drug target until the end of Phase III studies is risky, but working on the unvalidated targets identified by others is riskier still.

Andy Smith
ANDY SMITH OFFERS A LIFE SCIENCE INVESTOR'S PERSPECTIVE ON BIOPHARMA BUSINESS

Many classical disease targets have a number of therapeutic drug options, like the statins and the H2-receptor antagonists. Historically, pharmaceutical discovery groups have followed each other around, but there may be little comfort if a target takes a long time to invalidate.

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Aldeyra Expects Mid-2025 Refiling Of Reproxalap After Second CRL

 
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Aldeyra’s dry eye candidate reproxalap received a second FDA complete response letter, but the firm expressed confidence about refiling quickly based on two ongoing studies.

Pipeline Watch: 13 Approvals And 13 Phase III Trial Updates

Pipeline Watch is a weekly snapshot of selected late-stage clinical trial events and approvals announced by pharmaceutical and biotech companies at medical and industry conferences, in financial and company presentations, and in company releases and statements.

Roche’s Brain Shuttle Delivers In Alzheimer’s, Moves Ahead To Phase III

 

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Compass’ Bispecific BTC Contender Meets Phase II/III Endpoint

 
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