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Biliary Tract Cancer Fail Is Another Blow for Merck KGaA/GSK's Bintrafusp

Objective Response Rate Too Low For Filing

 
• By Kevin Grogan

Less than two months after bintrafusp failed to beat Merck & Co's blockbuster Keytruda in a Phase III NSCLC trial, Merck KGaA's bispecific fusion protein partnered with GSK has disappointed in a mid-stage study for biliary tract cancer.

Merck KGaA Darmstadt
Approval path for Merck KGaa's bintrafusp unclear

Merck KGaA and GlaxoSmithKline plc's high hopes for bintrafusp alfa have taken a fresh knock with the news that their high-profile oncology asset has failed another study, this time for biliary tract cancer (BTC).

Topline data from the 159-patient Phase II INTR@PID BTC 047 study evaluating bintrafusp as second-line treatment of patients with locally...

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