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Lilly’s Mirikizumab Hits All Marks In First Phase III Study For UC

 
• By Joseph Haas

Antibody targeting IL-23p19 yields clinical remission of ulcerative colitis after 12 weeks in the Phase III LUCENT-1 study. It also met all secondary endpoints, including reduction of bowel urgency.

Lilly gets positive Phase III data for its anti-IL-23 candidate in ulcerative colitis

Eli Lilly and Company’s development plans for mirikizumab took another step forward on 16 March as the pharma unveiled top-line data from the Phase III LUCENT-1 trial showing that the interleukin 23 (IL-23) blocker provided clinical remission of ulcerative colitis at 12 weeks and also hit all of the study’s secondary endpoints.

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Disappointing Asthma Phase II Results Take Wind Out Of Sanofi’s Amlitelimab

 
• By Andrew McConaghie

Sanofi’s OX40L candidate missed a Phase II primary endpoint, but the company believes it can still work in a sub-group of ‘heterogeneous inflammatory asthma’ patients.

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Amgen’s Imdelltra Sets The Pace In Small-Cell Lung Cancer

 
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Scancell Signs UK Match-Making Pact For Melanoma Vaccine

 
• By Kevin Grogan

The Oxford group has linked up with the NHS Cancer Vaccine Launch Pad.