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GvHD Could Yield To MaaT Pharma's Microbiome-Based Ecosystem Therapies

Phase III Studies Planned

 
• By John Davis

MaaT Pharma’s replacement bacterial ecosystem for the gastro-intestinal tract, MaaT103, has shown promise in top-line data from a Phase II study in patients with refractory aGvHD, energizing the microbiome field.  

city view of Lyon France
Lyon, France, Where MaaT Is Based • Source: Shutterstock

MaaT Pharma SA is planning to move its lead microbiome-based ecosystem therapy, MaaT013, into late-stage Phase III studies following promising top-line data from a Phase II study, HERACLES, in patients with acute graft-versus host disease (aGvHD). The data is the latest from microbiome-based companies using novel treatment approaches for a broad brush of indications. 

Although the number of patients in MaaT’s Phase II study was not large, and the trial single-arm and open-label, the...

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