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Roche Shelves Phase III Huntington's Candidate Tominersen

Follows Independent Committee Data Review

 
• By Sten Stovall

Roche’s Phase III of tominersen in Huntington's disease has been stopped after an independent interim review, but with no new or emerging safety signals reported, analysts presume efficacy was the problem.  

Huntington Disease
Analysts Suspect Study Halted By Inadequate Efficacy

Roche Holding AG has abandoned its Phase III trial studying the investigational drug tominersen in Huntington's disease, ending hopes the antisense oligonucleotide could offer a game-changing therapy for the debilitating condition, for which there is no effective treatment.

Termination of the pivotal GENERATION HD1 trial, announced 22 March, was the result of a pre-planned review of the Phase III study’s data by an

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