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Vertex’s ‘Slow Train To Pain’ R&D Rolls On

VX-548 Moves To Phase II

 
• By Sten Stovall

Vertex is advancing its sodium channel inhibitor VX-548 to mid-stage trials in the second half of the year as a potential treatment for pain after bunionectomy and abdominoplasty procedures.

VX-548 is the most recent of Vertex's channel-blocking agents to enter the clinic • Source: Alamy

Vertex Pharmaceuticals Incorporated is advancing VX-548 – another of its selective NaV1.8 inhibitors – into Phase II studies for treating acute pain in the second half of 2021, as the Boston-based group continues to assess ‘back up’ compounds that might have better pharmacological profiles and thus more attractive commercial prospects than its investigational asset VX-150.

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