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AstraZeneca/Daiichi Sankyo ADC Pact Continues Clinical Success In Breast Cancer

Early TNBC Efficacy Signs From Datopotamab Deruxtecan

 
• By Alaric DeArment

While much earlier in its development, the drug may be able to rival Gilead’s Trodelvy, which also targets TROP2 and showed similar response rates.

Doctor with Mammography - Image
AstraZeneca/Daiichi Sankyo's datopotamab deruxtecan shows early efficacy in triple-negative breast cancer • Source: Shutterstock

Early efficacy data for AstraZeneca PLC and Daiichi Sankyo Co., Ltd.’s antibody-drug conjugate (ADC) datopotamab deruxtecan in triple-negative breast cancer may bolster the drug’s position as a worthy successor to the two companies’ previously approved ADC, as well as a potential competitor against an approved Gilead Sciences, Inc. drug with the same target that has produced similar response rates.

The partners unveiled new data on 8 May from the triple-negative breast cancer (TNBC) cohort of the Phase I TROPION-PanTumor01...

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