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Allogene CAR-Ts’ Durability Remains A Question, But Strong Data So Far

Pivotal Trial Likely To Include Consolidation Dosing

 
• By Alaric DeArment

Complete response rates for ALLO-501 and ALLO-501A look comparable so far to Gilead’s Yescarta, though longer follow-up is needed to judge if durability matches as well.

Digital illustration of Cancer cell in colour background
Allogene announced data for its off-the-shelf CAR-Ts in non-Hodgkin's lymphoma • Source: Shutterstock

Allogene Therapeutics Inc.’s interim Phase I data for its allogeneic chimeric antigen receptor T-cell (CAR-T) therapies, ALLO-501 and ALLO-501A, look increasingly comparable to marketed autologous CAR-Ts in terms of response rates among patients with B-cell non-Hodgkin’s lymphomas, particularly with their added advantage of enabling consolidation treatment. But while those responses look durable so far, a lingering question is whether that durability will continue long enough to approach or match the durable responses seen with their autologous cousins.

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