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Sanofi Suffers Second Clinical Setback For Venglustat

Fails In Rare Genetic Kidney Disease Trial

 
• By Kevin Grogan

The French drugmaker has halted a pivotal trial of venglustat in autosomal dominant polycystic kidney disease, a few months after the drug failed as a treatment for Parkinson’s disease. Sanofi will go back to focusing on the therapy's potential in lysosomal storage diseases.

Sanofi Lyon
• Source: Alamy

Four months after failing in a mid-stage trial for Parkinson's disease, Sanofi's venglustat, once seen as a key candidate in its pipeline, has been discontinued as a treatment for an inherited condition that affects kidney function after a late-stage miss.

The French drugmaker has revealed that a pivotal Phase II/III study of venglustat in autosomal dominant polycystic kidney disease (ADPKD) did not meet futility criteria

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