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Terns Says Phase IIa Data Show Superior NASH Safety Profile In FXR Class

 
• By Joseph Haas

TERN-101 showed a superior safety and tolerability profile for lipid levels and pruritis compared to other FXR agonists in a mid-stage study. Terns is now looking to a NASH combo study with its THR beta agonist.

A professional businessman thinking while standing on a black arrow pointing forward in grey space concept
Terns thinks Phase IIa data for its FXR agonist is a key step in NASH combo therapy plans

Roughly three years into its effort to develop combination therapy addressing the various pathologies of non-alcoholic steatohepatitis, Terns Pharmaceuticals, Inc. has unveiled Phase II data demonstrating that its most advanced candidate – FXR agonist TERN-101 – offers the clinical benefits of its class with potentially a better safety and tolerability profile.

The Foster City, CA-based firm told an investor call on 14 June that TERN-101 is the first FXR agonist to...

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