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Biogen Gives Up On Gosuranemab After No Benefit Seen In Alzheimer's Study

Phase II TANGO Trial Was Targeting Anti-Tau For Early Disease

 
• By Sten Stovall

Biogen’s investigational anti-tau antibody gosuranemab has missed its primary efficacy endpoint in a Phase II study in patients with Alzheimer's disease, prompting the end of the trial and termination of the compound’s further clinical development.

TANGO Failure Leaves Debate Open About How, When To Block Tau • Source: Alamy

Hopes that the Phase II TANGO trial could potentially validate the anti-tau antibody approach to treating Alzheimer's have been dashed with the failure of gosuranemab to meet its endpoints, prompting Biogen, Inc. to end the study and scrap the investigational antibody’s clinical development.

The aim of TANGO was to evaluate both safety and efficacy on slowing rates of clinical progression in patients having mild cognitive impairment due to

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