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Madrigal Solidifies Presumed NASH Lead With 52-Week Data

 
• By Joseph Haas

Full-year findings for resmetirom reported at EASL confirm 16-week data in non-alcoholic steatohepatitis presented in 2020. Analysts say these data continue to de-risk the drug, but more important readouts await.

Madrigal office
Madrigal continues to build a solid data rationale behind resmetirom • Source: Madrigal Pharmaceuticals

Fifty-two week data from the first of two Phase III studies of Madrigal Pharmaceuticals, Inc.’s THR beta agonist resmetirom in non-alcoholic steatohepatitis (NASH) confirm earlier results of hepatic fat reduction and suggest improvements in fibrosis and inflammation – the incremental dataset also helps build resmetirom’s chance to be the first approved drug therapy in NASH.

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