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TB Alliance CEO On Less Toxic Treatment Regimens, Pretomanid Plans

 
• By Anju Ghangurde

TB Alliance CEO Mel Spigelman discusses a range of new and evolving aspects pertaining to the three-drug BPaL regimen for highly drug-resistant TB, including the ZeNix trial results and adding a licensee for pretomanid. He also notes how COVID-19 has had a “terrible impact” on efforts to tackle the TB pandemic.

TB
Efforts To Make TB Treatment Less Toxic • Source: Alamy

Linezolid-related toxicities are prominent and have been a cause for concern in the three-drug BPaL regimen for highly drug-resistant TB, which combines Johnson & Johnson’s Sirturo (bedaquiline) ), the TB Alliance’s pretomanid and Pfizer Inc..’s Zyvox (linezolid).

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