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TB Alliance CEO On Less Toxic Treatment Regimens, Pretomanid Plans

 
• By Anju Ghangurde

TB Alliance CEO Mel Spigelman discusses a range of new and evolving aspects pertaining to the three-drug BPaL regimen for highly drug-resistant TB, including the ZeNix trial results and adding a licensee for pretomanid. He also notes how COVID-19 has had a “terrible impact” on efforts to tackle the TB pandemic.

TB
Efforts To Make TB Treatment Less Toxic • Source: Alamy

Linezolid-related toxicities are prominent and have been a cause for concern in the three-drug BPaL regimen for highly drug-resistant TB, which combines Johnson & Johnson’s Sirturo (bedaquiline) ), the TB Alliance’s pretomanid and Pfizer Inc..’s Zyvox (linezolid).

In an interview with Scrip, Mel Spigelman, president and CEO of the TB Alliance, outlined some of the key aspects of the new Phase III ZeNix trial which demonstrated that the effectiveness of the BPaL regimen can be maintained with lower dosing of linezolid, thereby reducing a patient's exposure to its associated side effects

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