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Early Data From Ionis/Biogen’s BIIB080 Keeps Tau Alzheimer’s Hopes Alive

Unique Antisense Approach To Tau

 
• By Andrew McConaghie

While many other approaches have failed, Ionis and Biogen hope their novel oligonucleotide can stop toxic tau tangles forming in the brain.

Ionis HQ
Preclinical studies showed BIIB080 could prevent or even reverse Alzheimer's in transgenic mice - but the Phase I study did not examine clinical efficacy in humans.

While controversy around the US approval of Biogen’s beta-amyloid targeting Aduhelm rumbles on, its partner Ionis Pharmaceuticals has produced positive early-stage data from another Alzheimer’s candidate this time targeting tau, BIIB080.

Alongside beta amyloid, tau is the other key protein implicated in the disease, but over the years has seen similarly high numbers of failed drug candidates aimed at slowing or...

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