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After Years Of Setbacks, Marinus Closes In On Rare Epilepsy Opportunity

Ganaxolone Potential In Numerous Rare Conditions

 
• By Andrew McConaghie

After multiple failed attempts to treat rare conditions, Marinus is on the cusp of success with ganaxolone in genetic epilepsy, and has secured a new European partner in Orion.

Epilepsy brain
CDKL5 deficiency disorder (CDD) is a severe genetic form of epilepsy which can strike within the first three months of life. • Source: Alamy

After 18 years of setbacks and disappointments, Marinus Pharmaceuticals has submitted to the US Food and Drug Administration its candidate ganaxolone to treat a rare genetic form of epilepsy.

Established back in 2003, the company has just one drug candidate, GABA-A modulator ganaxolone, and over the years has seen it fail in trials against a string of conditions,

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