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Novartis's Kymriah Comes Up Short In NHL Study

Rivals Yescarta And Breyanzi Have Succeeded In Similar Trials

 
• By Kevin Grogan

The BELINDA study investigating Kymriah as second-line treatment in aggressive B-cell non-Hodgkin lymphoma has missed its primary endpoint, thwarting Novartis's hopes of getting the CAR-T therapy into earlier-stage use.

Novartis
• Source: Archive

Novartis AG's hopes of Kymriah becoming a blockbuster soon have taken a knock following the failure of the CAR-T therapy in a late-stage non-Hodgkin lymphoma (NHL) trial which could see the drug slip further behind Gilead Sciences, Inc.'s rival treatment Yescarta on the sales front.

The Swiss major has announced a disappointing update on the Phase III BELINDA study investigating Kymriah (tisagenlecleucel) in aggressive B-cell NHL after relapse or lack of response within 12 months...

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