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Poseida’s Solid Tumor CAR-T Shows Early Promise, But Safety Will Be Closely Watched

Promising Signs In Prostate Cancer

 
• By Andrew McConaghie

Developing CAR-Ts against solid tumors that are both safe and effective is proving a huge technical challenge, but San Diego biotech Poseida believes it has made important progress.

Poseida
Poseida Therapeutics went public in July 2020, but its stock has sunk since then because of CAR-T safety concerns and promise of competing pipeline cancer modalities.

In the wake of its own safety scare and the halting of a competitor’s trial, Poseida Therapeutics has bounced back with encouraging early safety and efficacy data from its CAR-T cell therapy candidate P-PSMA-101 for solid tumors.

Preliminary Phase I results from five heavily pre-treated patients with metastatic castrate-resistant prostate cancer (mCRPC) suggest efficacy and, just as

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