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Assembly Looks To Quickly Move Past ABI-H2158 Discontinuation

 
• By Alaric DeArment

The company’s triple-combination studies with vebicorvir and next-generation core inhibitor programs may hold more promise in hepatitis B.

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• Source: Shutterstock

Although Assembly Biosciences, Inc.’s decision to stop development of its Phase II hepatitis B virus (HBV) drug ABI-H2158 is a near-term black eye for the company, the firm still has two triple-combination studies with its lead core inhibitor, vebicorvir, up its sleeve as well as additional next-generation core inhibitors. And those drugs offer significantly greater chances of commercial success, the company says.

South San Francisco, CA-based Assembly said on 1 September that it would discontinue development of ABI-H2158 after four patients showed...

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