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Mirati’s Adagrasib Takes The Lead Among KRAS G12C Inhibitors In CRC

Monotherapy, Combo Data Outshine Amgen’s Lumakras

 
• By Mandy Jackson

Adagrasib may carve out a niche as the superior drug in colorectal cancer, but lung cancer – where Lumakras already is approved – is a larger market where Amgen has a big lead.

Yellow paper boat breaks out of order from other paper boats
Mirati's adagrasib may pull out from behind Amgen's Lumakras lead in lung cancer with an accelerated approval in colorectal cancer • Source: Alamy

Mirati Therapeutics, Inc. presented new data for its KRAS G12C inhibitor adagrasib alone and in combination with Erbitux (cetuximab) in colorectal cancer (CRC) that appear to show best-in-class efficacy, as a late-breaking abstract at the European Society of Medical Oncology (ESMO) annual meeting.

The drug previously generated better monotherapy efficacy in CRC than Amgen, Inc.’s competing product Lumakras (sotorasib), and the EGFR...

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