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Evelo’s Phase II Data Suggest Strong Position In Mild-To-Moderate Psoriasis

Analysts say biotech’s EDP1815 may offer similar efficacy to Amgen’s Otezla, with better safety. Evelo says data offer new proof for its small intestinal axis approach to inflammatory disease.

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Evelo candidate may offer relief for mild-to-moderate psoriais patients

Evelo Biosciences, Inc. unveiled Phase II data on 27 September indicating that its small intestinal axis-directed (SINTAX) therapeutic candidate EDP1815 can provide statistically significant clearance of psoriasis in mild-to-moderate cases with the safety profile of a placebo. The Cambridge, MA-based firm, a Flagship Pioneering portfolio company, says its SINTAX approach is differentiated from other microbiome therapies and may offer a new modality in immunology and other therapeutic areas.

The 249-patient study tested one-, four- and 10-capsule regimens of EDP1815 – an oral biologic that contains a single microbial strain optimized for pharmacological properties – against placebo in mild-to-moderate psoriasis

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