1. Scrip
  2. >>R&D
  3. >>Clinical Trials

Horizon Will Submit Krystexxa sBLA To Strengthen Clinical Profile In Gout

 
• By Jessica Merrill

A clinical trial confimred Krystexxa in combination with methotrexate increased response rates in patients with uncontrolled gout.

tree growing
Horizon sees a new opportunity to expand Krystexxa to more patients • Source: Alamy

Horizon Therapeutics plc has an ambitious goal to turn its gout therapy Krystexxa (pegloticase) into a $1bn brand and now has data to support an enhanced clinical profile for the drug in uncontrolled gout. The company announced on 25 October that the Phase IV MIRROR clinical trial testing Krystexxa in combination with the immunomodulator methotrexate showed significantly improved efficacy compared to treatment with Krystexxa alone in chronic refractory gout.

Improving Krystexxa's clinical profile has been a core part of Horizon's growth strategy for the brand since the company acquired the product in 2016 with the $510m acquisition of Crealta

Read the full article – start your free trial today!

Join thousands of industry professionals who rely on Scrip for daily insights

  • Start your 7-day free trial
  • Explore trusted news, analysis, and insights
  • Access comprehensive global coverage
  • Enjoy instant access – no credit card required
Start Free Trial

Already a subscriber?

More from Clinical Trials

Sanofi R&D Head’s Words Of Wisdom For Biotechs

 
• By Kevin Grogan

Houman Ashrafian tells delegates at Swiss Biotech Day that ‘literally only two things matter in our industry – target credentialing and differentiated pharmacology. The rest is execution.’

Marea Eyes Cardioprotective Benefit With ANGPTL4 Inhibition

 
• By Joseph Haas

Phase IIa data for ANGPTL4-targeted antibody shows reduced triglycerides and remnant cholesterol, which Marea asserts indicates potential to protect against cardiovascular outcomes.

First Win For AstraZeneca’s Enhertu In Early-Stage Breast Cancer Treatment

 
• By Andrew McConaghie

Already dominating in later lines of breast cancer treatment, Enhertu could now displace both chemotherapy combinations and Roche’s Kadcyla in early-stage HER2-positive patients.

In Brief: Strong OS Results For Immutep’s Eftilagimod/Keytruda Combo In Head And Neck Cancer

 
• By Sushmita Panda

Australian firm's combo of eftilagimod and Keytruda shows 17.6-month median overall survival in first-line HNSCC patients with low PD-L1, raising hopes for potential accelerated approval.

More from R&D

In Brief: Positive New Data For Aptose’s Triplet Therapy In 1L AML

 
• By Sushmita Panda

Aptose’s tuspetinib triplet shows early mutation-agnostic promise in new data from Phase I/II program for frontline acute myeloid leukemia.

Chinese Firms Build Obesity Clinical Pipeline But Face Wider Hurdles

 
• By Xu Hu

Despite the ability to initiate clinical trials quickly and having strong manufacturing capacity, Chinese companies are facing multiple challenges in the obesity space.

Aldeyra Plans To File Reproxalap Again With New Dry Eye Symptom Data

 
• By Joseph Haas

The biotech hopes a third time will be the charm after two FDA complete responses, with plans to position its eye drop as offering quicker onset of action.