Cortexyme Alzheimer’s Study Fails; Drug Slows Cognitive Decline In Some Patients

Subpopulation Efficacy Limited To One Of Two Primary Endpoints

Atuzaginstat targets a bacteria associated with Alzheimer’s disease. The higher of two doses showed a 57% slowing in cognitive decline in the Phase II/III GAIN trial in mild to moderate patients with P. gingivalis infection confirmed by saliva test.

Handrawn illustration of human brain on light grey background
Atuzaginstat inhibits gingipains created by P. gingivalis in the brain • Source: Alamy

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