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Rafael’s Devimistat Faces Double Whammy of Failed Trials in Pancreatic Cancer and AML

 
• By Ayisha Sharma

Rafael’s lead drug candidate has failed in a Phase III trial for pancreatic cancer and the company has been advised to stop a Phase III study of the product in AML.

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• Source: Shutterstock

Rafael Pharmaceuticals, Inc.’s lead candidate, devimistat, has hit the buffers in two Phase III trials. It has missed the primary endpoint in a Phase III study for first-line metastatic pancreatic cancer, while a second Phase III trial in relapsed or refractory acute myeloid leukaemia (AML) has been stopped on the recommendation of its independent data monitoring committee due to efficacy concerns.

“We are disappointed by the results,” admitted Rafael Holdings CEO Ameet Mallik. Nonetheless, the company was keen to continue the development of its only candidate

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