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Good News At Last For GSK With Daprodustat, But Safety Scrutiny Awaits

Likely To Dominate US Market If Approved

 
• By Andrew McConaghie

GSK could gain a first-in-class approval for anemia in chronic kidney disease in the US, but approval and uptake of the HIF inhibitor in non-dialysis patients remain uncertain.

Dialysis patient
While HIF inhibitors could replace ESAs in dialysis patients, use in non-dialysis patients offers the greatest potential • Source: Alamy

GlaxoSmithKline looks likely to dominate the US market for new oral treatments for anemia in chronic kidney disease (CKD) after success for daprodustat in two Phase III studies, as long as it can convince US Food and Drug Administration experts on its safety.

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