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Novartis and Molecular Partners’ Ensovibep Flunks In ACTIV-3 In Hospitalized COVID-19 Patients

Hopes Turn To Non-Hospitalized Patients

 
• By Ayisha Sharma

Ensovibep failed to meet thresholds for continued enrollment in the large NIH Phase III trial, forcing Novartis and Molecular to home in on the early COVID-19 setting instead.  

Ensovibep Was Administered Intravenously In The ACTIV-3 Trial • Source: Alamy

Novartis AG and Molecular Partners AG will halt recruitment of hospitalized COVID-19 patients in the ensovibep arm of the Phase III ACTIV-3 study after it failed a futility analysis. Their attentions now turn to the candidate’s potential in a non-hospitalized setting in another Phase II/III study, EMPATHY.

Molecular’s lead infectious disease candidate, ensovibep, did not meet the thresholds necessary to continue enrolment, the data and safety monitoring...

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