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Janssen/Legend’s Cilta-Cel Consistent In Earlier Myeloma, Longer-Term Results

Bristol’s Abecma Beat CAR-T To Market, Maybe Not In Second-Line

 
• By Mandy Jackson

The partners reported initial data at ASH for their BCMA-targeting CAR-T therapy in second-line multiple myeloma that appear consistent with longer-term results and ahead of their main competitor, Bristol’s Abecma.

Myeloma multiplex leukemia cancer 3d color render isometric view
Cilta-cel is closing in on the second line in multiple myeloma • Source: Alamy

Janssen Pharmaceutical Cos. and Legend Biotech Corp. are seeing similar response rates for their BCMA-targeting CAR-T therapy ciltacabtagene autoleucel (cilta-cel) in earlier multiple myeloma settings. The partners presented data at the American Society of Hematology (ASH) meeting that show response rates in multiple myeloma patients in the second through fourth lines of treatment that match the high and long-lasting responses seen in patients with much more advanced forms of the disease.

The data were revealed on 12 and 13 December, almost six weeks after Janssen, a Johnson & Johnson subsidiary,...

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