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Novartis’s Ligelizumab Founders In Phase III Despite Positive Predictions

Fails To Top Xolair in CSU trials

 
• By Ayisha Sharma

Novartis’s ligelizumab failed to show superiority over standard of care Xolair, subverting hopeful analyst expectations and changing the firm’s focus in chronic spontaneous urticaria to a BTK inhibitor asset.  

CSU Causes Itchy, Painful Hives And Angioedema • Source: Alamy

Novartis AG’s ligelizumab has underperformed in two Phase III studies despite positive analyst sentiment, shifting attentions to its other late-stage skin candidate, remibrutinib.

Ligelizumab is in two Phase III studies for chronic spontaneous urticaria (CSU), the unpredictable skin disease that causes itchy, painful...

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• By Anju Ghangurde

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• By Jessica Merrill

The company, with partner Bristol Myers Squibb, has a three-wave development strategy for BNT-327: “establish, combine, broaden.”