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Xian Under Lockdown, mRNA Vaccines Remain Elusive In China

Domestic Shot May Need Two Boosters Vs Omicron

 
• By Brian Yang

A relatively large outbreak in another major Chinese city after original epicenter Wuhan heightens the urgency for a more effective mRNA vaccine.

XIAN A VIBRANT CITY IN CHINA ENCOUNTERS STRICT LOCKDOWN AFTER WUHAN IN JAN 2020
XIAN IN SEPTEMBER 2021 BEFORE THE STRICTEST LOCKDOWN AFTER WUHAN IN JANUARY 2020 • Source: Brian Yang/Scrip

Xi'an, a city of 13 million people in Northeastern China, is under strict lockdown amid a regional COVID-19 outbreak, the worst in the country since January 2020 when similarly-sized Wuhan was placed under drastic restrictive measures.

Most immediately, the move has hit hard those in the city seeking healthcare and medical emergency services. In one publicized...

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Chinese Biotech VC/PE Fundings Rise But Still Modest

 
• By Dexter Jie Yan

LTZ Therapeutics and Beijing Sungen Biomedical are among the Chinese biotechs raising new funding, of around $40m each, based on their clinical assets with novel mechanisms of action. While fundings have risen, they remain moderate however.

Degron Eyes Deals For Novel Molecular Glue Degrader Assets

 
• By Dexter Jie Yan

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Ascentage Broadens Horizons As Pipeline Shows Renewed Promise

 
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Ascentage will share at ASCO new clinical data on its Bcl-2 inhibitor lisaftoclax, part of the Chinese firm's novel pipeline, on which its CEO shared with Scrip plans and strategy, along with some views on the use of RWD in China.

Strong Data For CARsgen’s CAR-T In Late-Line Gastric Cancer

 
• By Dexter Jie Yan

In first confirmatory randomized controlled trial of any CAR-T therapy in solid tumors, CARsgen’s Claudin 18.2-targeting satri-cel reduced risk of death or disease progression by 63% in Chinese patients with gastric/gastroesophageal junction cancer.

More from Focus On Asia

Deal Build-Up Amid Early ‘Deep’ Response For IGI’s Trispecific In Myeloma

 
• By Anju Ghangurde

IGI CEO tells Scrip about the “very encouraging” feedback at ASCO to promising early data for the firm's first-in-class investigational trispecific antibody in multiple myeloma. Is a licensing deal in the offing?

Degron Eyes Deals For Novel Molecular Glue Degrader Assets

 
• By Dexter Jie Yan

Pursuing first-in-class molecular glue degraders using undruggable targets could eventually help Degron Therapeutics land sizable asset-based deals, CEO Lily Zou tells Scrip.

ASCO: Lupin Presents Early Data On PRMT5 Inhibitor

 
• By Vibha Ravi

ASCO sees the debut of Lupin’s PRMT5 inhibitor candidate LRNP7457, currently in Phase I studies in India. While no drug with this mechanism of action has been approved anywhere so far, several candidates are in clinical trials.