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PureTech Takes On Roche With Improved IPF Drug

Modified Version Of Esbriet Seems Safer

 
• By Ayisha Sharma

The firm’s lead candidate has shown strong tolerability in an early-stage trial for idiopathic pulmonary fibrosis, sparking hopes for registration-enabling studies and a streamlined development plan.      

Squiggly lines from start to finish line, a straight line from start to finish underneath. Streamlined concept.
PureTech Hopes To Piggyback Off Esbriet Data For A Smoother Filing • Source: Alamy

PureTech Health plc will start a dose-ranging study of LYT-100, a modified version of Roche Holding AG’s idiopathic pulmonary fibrosis (IPF) blockbuster Esbriet as part of its plan to advance the candidate into registrational development via a simplified US regulatory pathway.

The announcement came as data from a Phase I trial in 49 healthy adults aged between 60 and 79 showed...

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