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Scrip’s Rough Guide To Targeted Protein Degradation

Drugging The Undruggable

 
• By Alexandra Shimmings

By hijacking a process that cells use to keep themselves shipshape, targeted protein degradation has become a hot new area of drug development. Scrip takes an in-depth look at the field ahead of a wave of data expected this year from early candidates that will give some insight into whether this strategy will truly open a new way to combat disease.  

Ubiquitinin
Ligase enzyme tags protein for degradation by attaching a ubiquitin molecule • Source: Alamy

Targeted protein degradation, or TPD, has been steadily gaining attention in recent years as a highly promising new drug development strategy that has already attracted significant investment and big pharma attention.

With observers eagerly awaiting early clinical data for a range of novel TPD candidates, Scrip explains how these products work,...

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