AstraZeneca/Merck’s Lynparza Is First Adjuvant Option For BRCA-Positive Breast Cancer

One of two PARP inhibitors approved in breast cancer, Lynparza may have the adjuvant breast indication all to itself for a while. One analyst projects a $1.5bn revenue opportunity for the indication.

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AstraZeneca plants flag with first adjuvant option for BRCA+ breast cancer • Source: Alamy

AstraZeneca PLC and partner Merck & Co., Inc. have added a first-in-class indication to PARP inhibitor Lynparza’s (olaparib) US label, making the drug the first approved adjuvant therapy for early, high-risk breast cancer patients with BRCA mutations.

One of two PARP inhibitors approved in breast cancer – along with Pfizer Inc.’s Talzenna (talazoparib) – Lynparza is...

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