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Exelixis’s Cabometyx Plus Tecentriq Disappoints In Lung Cancer

Earlier Data Showed Better Results For Roche Pairing

 
• By Joseph Haas

While a combo regimen of Cabometyx and Tecentriq actually showed a lower response rate in lung cancer than a 2020 readout, a doublet of Cabometyx/Keytruda showed promise in head-and-neck cancer.

Lung Cancer
Updated data put Cabometyx's utility in lung cancer in doubt

Exelixis, Inc. will present updated results from a combination trial it is conducting with Roche Holding AG in solid tumors at the American Society for Clinical Oncology annual meeting, being held 3-7 June, and also will outline data from a small investigator-initiated study of its tyrosine kinase inhibitor (TKI) Cabometyx with Merck & Co., Inc.’s Keytruda in recurrent metastatic head-and-neck squamous cell carcinoma (RMHNSCC).

COSMIC-021, a 914-patient, Phase Ib basket study, is testing Cabometyx (cabozantinib) monotherapy as well as combination therapy with Roche’s anti-PD-L1...

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