Bristol Confident To Move Deucravacitinib Into Phase III Lupus Trial

A Phase II study testing the TYK2 inhibitor in systemic lupus erythematosus met the primary endpoint. CMO Samit Hirawat talked to Scrip about the data and future development.

Lupus Ribbon
Bristol Myers is moving its TYK2 inhibitor into Phase III in lupus • Source: Shutterstock

Bristol Myers Squibb Company is hopeful that its oral tyrosine kinase 2 (TYK2) inhibitor deucravacitinib could offer a new potential mechanism of action to treat systemic lupus erythematosus (SLE), a challenging condition for drug development. The company announced on 1 June that a Phase II trial testing deucravacitinib in SLE met the primary endpoint and that it will advance the drug into Phase III testing in lupus by the end of the year.

The data are being presented as a late-breaking abstract at the European Alliance of Associations for Rheumatology (EULAR) Congress, and chief medical officer Samit Hirawat talked to

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