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Mirati Seeks Differentiation, Amgen Invests In Combos To Dominate KRAS G12C Field

Biomarker Data Confirm Amgen Strategy; Mirati’s Drug Works In CNS

 
• By Mandy Jackson

Amgen outlined the most frequent co-mutations in treatment-resistant lung and colorectal cancers at ASCO, while Mirati’s adagrasib showed efficacy in active CNS metastases in lung cancer patients. 

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Amgen was first to market but Mirati is close behind • Source: Shutterstock

Amgen, Inc. was the first to bring a KRAS G12C inhibitor to market with the US Food and Drug Administration approval of Lumakras (sotorasib) a year ago and Mirati Therapeutics, Inc. is on track for a second-place finish with potential FDA approval of adagrasib in December of this year. However, both companies still have a lot of work to do to illustrate the best use of their therapies and each attempted to advance that understanding at the American Society of Clinical Oncology meeting.

As Amgen vice president of late-stage oncology development I-Fen Chang noted in an interview with Scrip, “We're just at the...

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• By Alaric DeArment

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Deal Build-Up Amid Early ‘Deep’ Response For IGI’s Trispecific In Myeloma

 
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ASCO: Carvykti Data Raise Possibility Of Myeloma Cure

 
• By Alaric DeArment

J&J presented data at the American Society of Clinical Oncology meeting showing more than five-year disease- and therapy-free survival, but a myeloma working group will need to define what makes a cure.

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Merus Raises $300m After ASCO Success

 
• By Andrew McConaghie

The company is raising the money to fuel development of its head and neck cancer candidate, petosemtamab, on the back of promising early data. Some analysts are stopping short of declaring it the winner against a rival product from Bicara, however.

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• By Andrew McConaghie

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