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Potential For Functional Cure Opens Up With GSK’s Hepatitis B Candidate

Durability Test Remains

 
• By Andrew McConaghie

Bepirovirsen made the hepatitis B virus undetectable in nearly 30% of patients in a Phase II study – but it remains to be seen whether this response be sustained once treatment with the novel antisense product ends.

#EASL
Hepatitis B was a big focus at this year's International Liver Congress, hosted by European Association for the Study of the Liver (EASL) in London • Source: Steve Forrest & Andrew McConnell / EASL

GSK has unveiled promising interim Phase IIb results of hepatitis B candidate, bepirovirsen, which could put it on the path to providing a functional cure for more chronic patients.

The antisense oligonucleotide therapy rendered the virus undetectable in the blood of nearly 30% of patients on the B-Clear study after 24 weeks of treatment, regardless of whether it was used as a monotherapy or in combination with

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