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AstraZeneca Looks To Muscle In On BMS-Dominated Neoadjuvant NSCLC Setting

 
• By Alaric DeArment

Without disclosing data, the company reported positive pathological complete response data from the AEGEAN study of its PD-L1 inhibitor Imfinzi in neoadjuvant NSCLC, where BMS’s Opdivo won approval in March.

AstraZeneca announced Phase III results from the AEGEAN trial of Imfinzi in neoadjuvant NSCLC • Source: Shutterstock

Although AstraZeneca PLC wasn’t one of the first PD-1/LI sponsors to make it to market, new Phase III data may position the company’s Imfinzi (durvalumab) to be an early entrant for neoadjuvant treatment of non-small cell lung cancer (NSCLC), a space where Bristol Myers Squibb Company’s PD-1 inhibitor Opdivo (nivolumab) had the distinction of winning US Food and Drug Administration approval earlier this year and where other PD-1/L1 players are hoping to compete as well. 

The British drug maker is busy at work making Imfinzi a player in earlier lines of treatment, such as neoadjuvant...

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More from Clinical Trials

Alkermes Two-For-Two In Narcolepsy As Alixorexton Succeeds In NT2 Trial

 
• By Alaric DeArment

The drugmaker plans to move into Phase III development of the drug, which has now posted positive Phase II results in narcolepsy types 1 and 2.

MASH Updates: Sagimet, Altimmune, GSK Discuss Development Plans At AASLD

 
• By Joseph Haas

Sagimet may shift focus to later-stage MASH while it lines up Phase III financing. Altimmune expects its dual agonist to show efficacy and tolerability, while GSK is readying efimosfermin as the third FGF21 analog into Phase III for MASH.

enGene’s Detalimogene On Track For H2 2026 FDA Filing In NMIBC

 
• By Alaric DeArment

The company announced data from patients enrolled after a protocol amendment designed to bring the study in line with non-muscle invasive bladder cancer (NMIBC) standards of care.

A Week Is A Long Time In Biotech, Just Ask Galecto

 
• By Kevin Grogan

A long time on the ropes, the US firm is now well-financed to advance potential candidates for essential thrombocythemia and myelofibrosis into the clinic.

More from R&D

A Week Is A Long Time In Biotech, Just Ask Galecto

 
• By Kevin Grogan

A long time on the ropes, the US firm is now well-financed to advance potential candidates for essential thrombocythemia and myelofibrosis into the clinic.

AnaptysBio Scraps Rosnilimab Ulcerative Colitis Trial After Phase II Miss

 
• By Sushmita Panda

The biopharma plans to advance the PD-1 agonist in rheumatoid arthritis despite its failure in ulcerative colitis.

Neurocrine’s Depression Drug Misses In Phase II

 
• By Andrew McConaghie

Small study fails to turn up efficacy signals in the major depressive disorder candidate, leaving Neurocrine with one remaining depression candidate in development.