VBL Therapeutics Switches Tack After Pivotal Gene Therapy Ovarian Cancer Fail

Israeli Firm's Stock Sinks

The Israeli firm’s gene therapy asset has disappointed in an advanced ovarian cancer study, leaving experts skeptical of its potential in other tumors and the company turning to an earlier program.  

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VBL Therapeutics is pinning its hopes on a preclinical anti-inflammatory program after its lead gene therapy candidate for ovarian cancer, ofra-vec (ofranergene obadenovec, VB-111), flunked the Phase III OVAL trial.

VBL’s stock dropped by 79% pre-market on the NASDAQ upon announcement of the news, as doubts were raised about the product's other indications and the firm has little else in its pipeline

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