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Innate Lead Candidate Fails In Head And Neck Cancer But Partner AZ Offers Hope In NSCLC

 
• By Ayisha Sharma

Innate’s lead candidate has reached the end of the road in head and neck carcinoma after a disappointing interim Phase III trial analysis but hope remains that a combination with partner AstraZeneca's Imfinzi could succeed elsewhere.  

Paper lungs with a hole on one side, depicting lung cancer, on blue background
AstraZeneca Hopes To Position Imfinizi In The Adjuvant Lung Cancer Setting • Source: Shutterstock

Innate Pharma S.A.’s lead drug candidate, monalizumab, faces a trial discontinuation in head and neck cancer following poor efficacy signals for the first-in-class immune checkpoint inhibitor in a Phase III trial, narrowing its hopes to a combination regimen with partner AstraZeneca PLC’s Imfinzi in lung cancer.

The French firm revealed an interim analysis of the INTERLINK-1 trial fell short of a pre-defined efficacy threshold. INTERLINK-1 was...

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Sanofi Revels In More Positive Rilzabrutinib Data

 
• By Kevin Grogan

The oral BTK inhibitor impresses in a Phase II trial for IgG4-related disease.

How AstraZeneca Aims To Stay Ahead In Lupus As New Competition Looms

 
• By Andrew McConaghie

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Biogen Lays Out Cadence For Felzartamab Data In Kidney Diseases

 
• By Jessica Merrill

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In Brief: Gilead HIV Trials On Hold Over Safety Signal

 
• By Sushmita Panda

The FDA has paused Gilead’s HIV trials of GS-1720 and GS-4182 over safety concerns. The company’s upcoming PrEP PDUFA looks to be unaffected.

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In Brief: Gilead HIV Trials On Hold Over Safety Signal

 
• By Sushmita Panda

The FDA has paused Gilead’s HIV trials of GS-1720 and GS-4182 over safety concerns. The company’s upcoming PrEP PDUFA looks to be unaffected.

Pharma’s Space Trails Entering Transformative Era - Keytruda’s Been There

 
• By Anju Ghangurde

Merck and Lilly are among the leading pharma players using space-based research to power drug development. From reusable satellites to process drugs in low earth orbit to biomanufacturing labs experts discuss R&D opportunities in the starry canvas above.

Spain’s SpliceBio Secures Sanofi and Roche Support In $135m Financing

 
• By Kevin Grogan

Series B cash will be used to advance its Stargardt disease gene therapy.