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Beam Therapeutics’ Base-Edited CAR-T Placed On Hold

Latest Off-The-Shelf Therapy To Be Delayed

 
• By Andrew McConaghie

Beam is the latest allogeneic CAR-T developer to face a regulatory hold-up, but other candidates using its pioneering base-editing technology are now progressing.

DNA bases
Beam is a pioneer of a more precise technique in which 'single-letter' editing of DNA and RNA is possible. • Source: Shutterstock

The US Food and Drug Administration has placed a hold on Beam Therapeutics’s preclinical candidate, BEAM-201. It is the latest in a string of off-the-shelf cell therapies to be placed on hold by the regulator, though competitors in the field are now progressing after clearing safety checks.

Beam, which specializes in the new base-editing technology for gene therapy, said on 1 August that the regulator had put a hold on its request to start Phase I

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