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TED Talk: Viridian’s Early Data Indicate Strong Competitor To Horizon’s Tepezza

 
• By Joseph Haas

Viridian says Phase I/II data for its thyroid eye disease candidate outperforms Horizon’s Tepezza on multiple measures. Company plans quick advancement into Phase III for VRDN-001.

Thyroid eye disease
Thyroid eye disease is characterized by bulging of the eye • Source: Shutterstock

Horizon Therapeutics plc has had the thyroid eye disease (TED) market cornered since launching Tepezza (teprotumumab) in early 2020 and establishing a fast blockbuster drug, but Viridian Therapeutics, Inc. says its VRDN-001, an insulin-like growth factor-1 receptor (IGF-1R) antagonist, is showing better efficacy in clinical trials designed to mimic those conducted by Horizon for Tepezza. The data are early, however, and from small number of patients so Viridian will still have work to do to successfully bring a competitor to market.

Viridian unveiled six-week data on 15 August from a Phase I/II study in a cohort of eight patients who received...

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• By Aakash Babu

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