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ESMO: Mirati’s Adagrasib Appears To Maintain CRC Edge In KRAS Race

 
• By Alaric DeArment

The company is reporting strong ORR, durability and PFS at ESMO in heavily pretreated colorectal cancer, an indication where Amgen’s Lumakras has struggled.

Mirati's adagrasib appears to have maintained its edge in the KRAS race • Source: Shutterstock

Mirati Therapeutics, Inc.’s adagrasib stands to reinforce its competitive positioning among KRAS G12C inhibitors with new data showing the drug’s efficacy in advanced colorectal cancer (CRC), as a monotherapy and in combination with Eli Lilly and Company’s EGFR inhibitor Erbitux (cetuximab).

Mirati announced a late-breaker presentation of data on 7 September from the Phase I/II KRYSTAL-1 clinical trial at the European...

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