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Does Zydus’ Promising CAPS Candidate Have An Edge Over Novartis’ Ilaris?

Potential In Chronic Inflammatory Diseases

 
• By Vibha Ravi

Zydus has established proof of concept for ZYIL1, a NLRP3 inflammasome inhibitor to treat cryopyrin-associated periodic syndromes, via Phase II trials in Australia. Will the oral drug have an upper hand over injectables like Novartis’ Ilaris?

Rare Disease Sign
Pharma Has Increased Focus On Rare Diseases • Source: Shutterstock

Zydus Lifesciences Limited recently announced achieving positive proof of concept in a Phase II clinical study of its NLRP3 inflammasome inhibitor ZYIL1 to treat cryopyrin-associated periodic syndromes (CAPS), a rare, hereditary, life-long spectrum of auto-inflammatory conditions.

The Phase IIa, prospective, single arm, open-label study in Australia to determine safety and tolerability profile of orally administered small...

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