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Axcella Hopes Interim NASH Data Can Help Extend Its Financial Runway

 
• By Joseph Haas

Axcella’s AXA1125, a therapeutic combination of amino acids, shows liver stiffness, liver enzyme and fat reduction benefits in Phase IIb interim look, but the firm lacks the cash to complete the trial.

NASH liver
Axcella uses combinations of amino acids to fight disease, including NASH • Source: Shutterstock

Non-alcoholic steatohepatitis is a hard therapeutic space to stand out in, but cash-poor Axcella Therapeutics, Inc. is trying to get attention from partners or financial backers with positive interim data from a Phase IIb study. The biotech’s endogenous metabolic modulator AXA1125 met statistical significance on several secondary NASH endpoints in a scheduled interim look, but Axcella may not have enough money to get to final data expected in early 2024.

On 29 September, the Cambridge, MA-based company reported that AXA1125, a therapeutic combination of “generally recognized as safe” amino acids that can provide target regulation and signaling in various disease states, provided statistically significant improvements in liver stiffness as measured

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