Merck’s Sotatercept Hits Phase III Marks In Mid-Stage PAH Patients

The pharma’s pulmonary arterial hypertension candidate, touted as a future blockbuster seller, showed benefit on six-minute walk distance and several secondary endpoints in Phase III STELLAR.

Merck & Co.
Merck shows sotatercept can offer benefit in PAH patients

Merck & Co., Inc. hit a key milestone in advancing its cardiovascular pipeline on 10 October, announcing a successful Phase III trial for sotatercept, a reverse-remodeling agent proposed to rebalance TGF-beta superfamily signaling, in mid-stage pulmonary arterial hypertension (PAH) patients. The pharma said it will move “with urgency” in speaking with regulators about an approval pathway for sotatercept.

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