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Amgen’s Olpasiran Maintains Competitive Profile In Lp(a) Class

AMG 133 For Obesity Is One To Watch In CV Portfolio

 
• By Mandy Jackson

The lipoprotein(a)-lowering antisense drug olpasiran reduced the cardiovascular disease risk factor Lp(a) by up to 101.1% relative to placebo. A Phase III trial will begin in December. 

Human heart with blood vessels
About 20% of people have elevated Lp(a) levels that increase their cardiovascular disease risk • Source: Shutterstock

Amgen, Inc. is looking to improve upon known mechanisms of action to build out its portfolio in cardiometabolic diseases beyond its LDL cholesterol-lowering biologic Repatha (evolocumab), such as with its lipoprotein(a)-lowering drug olpasiran, and full Phase II results released at the American Heart Association Scientific Sessions suggest it may be competitive with Novartis AG’s leading Lp(a) candidate pelacarsen.

The company used a 7 November analyst call after its presentations at the AHA annual meeting to discuss emerging data for Phase III-ready olpasiran and AMG 133, which will enter...

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