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Idorsia/J&J’s Aprocitentan Hits Phase III Mark, Could Become First ET-1 Antagonist For Hypertension

 
• By Ayisha Sharma

The first-in-class ET-1 receptor antagonist has met the primary endpoint in a pivotal resistant hypertension trial, sparking filing plans that could see the drug establish a stronghold in the multi-billion dollar market.  

Red blood cells
Resistant Hypertension Patients Often Have Other Comorbidities • Source: Shutterstock

Idorsia Pharmaceuticals Ltd and Johnson & Johnson’s aprocitentan has succeeded in a Phase III resistant hypertension trial with plans in place for a US filing by year end, which could see it become the first drug of its class on the market.

The pivotal PRECISION trial investigated aprocitentan with standard therapy in more than 700 people with resistant hypertension, which is defined as the inability of at least three drug classes to control blood pressure to target (diuretics, calcium channel blockers and

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